Nikola Kalinic had to come on to replace Santa Cruz after just 11 minutes because of a problem with his groin - but Kean insists it was just a precaution.
He said: "When he went to spin at the back post, he just felt something high up in his groin.
"Rather than have him go through that and try to shake it off, we got him off the pitch, got him iced up, and hopefully that will settle down quickly."